BRAIN CHOLECYSTOKININ SYSTEM IN NEUROTIC PATHOLOGY

Violation and discoordination of mental processes leads to changes in the ratio main neurotransmitters content further disorders. A significant role such is played by neuropeptides, particular anti-anxiety ones, which include cholecystokinin (CCK) its receptors. It has been established that stimulation CCK receptors modulates mesolimbic system reward, anxiety satiety. CCK-1 (the intestine) CCK-2 type CNS stomach) are isolated. In central nervous system, short O-sulfated form CCK-8 non-sulfated CCK-5 predominate. was shown effect on corresponding inhibits GABA-ergic subcortical nuclei, mediates transmission nerve signals from endocannabinoid system. number receptors, their agonists antagonists were found body. Potentially, blockers these can be combined with other agents for treatment diseases. CCK, it an anxiogenic effect, realized through influence a selective agonist. There information CCK-4 causes effects due neurotransmitters, particular, neuromodulation dopaminergic interact neurotransmission systems. behavioral tests, anxiolytic receptor shown. The participation this pathogenesis confirmed non-selective "elevated cross-shaped maze" test. At same time, reduced clinical studies, they suppressed panic when administered as bolus. However, problem bioavailability compounds remains unsolved. diversity expression all parts brain also complicates application greatly. So, involved development manifestations pathology, but there prospects medical use substances regulate functional activity